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Article VI, Paragraph 2 of the Constitution provides:

This Constitution, and the Laws of the United States which shall be made in pursuance thereof; and all treaties made, or which shall be made, under the authority of the United States, shall be the supreme law of the land; and the judges in every state shall be bound thereby, anything in the constitution or laws of any state to the contrary notwithstanding.

Because of the Supremacy Clause, the Constitution is the Supreme Law of the Land. Laws that violate the Constitution  can be declared unconstitutional.  State laws that conflict with federal law will be preempted.

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